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For example, MR-Egger estimates for anxiety disorders (OR = 0.81, 95% CI: 0.591.11) and autism (OR = 0.62, 95% CI: 0.321.20) included the null value

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This two-way influence creates a dynamic loop where diet, microbiome, and behavior all play a role in modulating GLP-1 secretion

In the SURPASS-2 study, the three doses of tirzepatide (5, 10, and 15 mg once weekly) were tested with the GLP-1RA semaglutide (1 mg once weekly) as a comparator in patients not optimally controlled on monotherapy with metformin (71)

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