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Metformin reduces the synthesis of pro-inflammatory cytokines in macrophages at a molecular level by blocking the transition from monocytes to macrophages via the AMPK-STAT3 pathway (Vasamsetti et al., 2015)

doi: 10.1038/s41420-019-0146-x 76 LuoXGongHBGaoHYWuYPSunWYLiZQet al

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Even those taking trace levels of lithium (roughly 0.4mg) have experienced improved mood during a four-week period