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Macrocytic anemia occurs when your body doesnt have enough normal red blood cells, and can cause symptoms including muscle weakness and paresthesias (paresthesias is the technical term for the pins and needles feeling on your skin)

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However, some individuals may prefer evening administration, particularly if they experience any mild detoxification effects that might be better tolerated during sleep

Risk factors include recent surgery, prolonged immobility, cancer, pregnancy, and genetic clotting disorders