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In phase 2 clinical trials conducted in adult populations, retatrutide demonstrated substantial weight-loss efficacy, with reported reductions of up to 24.2% over a 48-week treatment period

Human data is still limited, but the improved bioavailability helps explain why some patients can eventually reduce to three times weekly dosing

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Before undergoing the test, fasting may be required

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The prior authorization request asks specifically: "Does the patient have a diagnosis of type 2 diabetes mellitus (A1C 6.5% or fasting glucose 126 mg/dL)?" If the answer is no, the request auto-denies