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Study Design and Population The trial enrolled 445 participants across three groups in a 1:1:1 randomization: Retatrutide 9mg group: 148 participants Retatrutide 12mg group: 149 participants Placebo group: 148 participants Participants had an average baseline weight of 112.7 kg (248.5 lbs) and a mean BMI of 40.4 kg/m
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12 Further, in older overweight and obese individuals undergoing a diet, despite similar body weight (~9%) and fat mass losses (~6.9%), RET resulted in less lean mass loss (2%) compared to endurance exercise alone (5%) or a combination of the two (3%)
