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Preclinical studies with SAR425899 clearly demonstrated dual receptor agonism in vitro and in preclinical in vivo studies, with a higher potency for the GLP1R than for the glucagon receptor in order to counterbalance the GCGR mediated increase of blood glucose levels through GLP-1 agonism 11,12,13

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59 (Suppl 1): S147S149, discussion S195S196

3163, was created for claims alleging that GLP-1 receptor agonist drugs caused non-arteritic anterior ischemic optic neuropathy (NAION) and related vision loss injuries