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10.1136/bmjopen-2018-025722 127 ZhangR

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It may mean you need more time to build your foundation before you can make a safe transition off your medication

Initial treatment often requires daily or weekly injections depending on deficiency severity

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Patients assigned to tirzepatide showed a 20.9% BW loss after 36 weeks with an additional 5.5% reduction after 52 weeks, while those who switched to placebo experienced a 14% weight regain, confirming the findings from STEP 4 supporting the chronicity of obesity and the need for continuous treatment