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Compared to Tirzepatide's dual GIP/GLP-1 mechanism achieving 20.2% weight loss at 72 weeks, Retatrutide's addition of glucagon receptor agonism appears to enhance energy expenditure and hepatic lipid metabolism

Bioavailability: Pancorbo D, et al

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For people with colitis, this side effect can be particularly challenging because diarrhea is already a symptom of their condition

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