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Within activated macrophages there are distinct changes in TCA cycle activity that lead to the accumulation of TCA cycle intermediates, particularly fumarate and itaconate

2020;13:S29

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The concept of using pathogens to modulate the immune system has been accepted and applied in oncology for some time

In addition, the evidence that parasite-derived products interact directly with endocrine cells to influence their communication with macrophages to prevent -cell death and enhance function is discussed