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The article says people already on antihypertensives should be monitored closely, because a GLP-1-related blood pressure reduction could mean their antihypertensive regimen needs revisiting to prevent hypotension or orthostatic symptoms

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However, you should always have new symptoms evaluated and notify your fibroid specialist if your symptoms begin to worsen or impact your normal activities

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The review synthesized findings from cell-culture experiments (human dermal fibroblasts, keratinocytes, irradiated fibroblasts), animal models (rats, mice, pigs, dogs), and human cosmetic-science studies of topical formulations

the PK-PD disconnect supports this