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This crucial phase of the malady, in analogy with other viral infections and to a widely accepted pharmacological praxis, should be timely treated either with etiotropic drugs (which in COVID-19 case are still lacking) as well as with host-directed agents to manage/prevent the symptoms (Sestili and Stocchi, 2020)

Theoretical risks Long-term or high-frequency use raises theoretical concerns about copper accumulation

Side effects and safety TB-500 has shown a favorable safety profile in animal studies

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