M., Lopatkin, A
The exact trigger for BBB dysfunction is incompletely understood but the hypothesis most widely agreed upon proposes that an early focal inflammation due to activated lymphocytes traversing the BBB may trigger a complex, sustained inflammatory cascade, eventually leading to demyelination and axonal loss (Filippi et al., 2016)
Orlistat (Alli, Xenical) works by blocking fat absorption and predictably causes fatty, loose stoolsmaking it unsuitable for patients seeking to avoid diarrhea
Sensitivity is the lowest value of marker/analyte in assay buffer where the assay can statistically differentiate from background
Once your body reaches steady state, the difference between peak and trough levels narrows considerably, and the end-of-week hunger effect diminishes or disappears entirely for most people
For the vast majority of patients without concerning thyroid history, the established benefits significantly outweigh the unproven thyroid concerns