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showed that administration of L-carnitine at a dose of 170 mg/kg to rabbits along with hypercholesterolemic diet, induced significant reduction in plasma VLDL-cholesterol, VLDL-triglycerides and increases the activity of hepatic acyl-CoA cholesterol acyl transferasa 23

Chirichella et al

When patients increase from 0.25 mg to 0.5 mg weekly (or equivalent oral doses), the GI tract is exposed to stronger receptor activation

M., Narva, A

Because yerba mate contains a decent amount of caffeine, drinking too much of it can also cause some of the side effects associated with excess caffeine intake, such as jitteriness, insomnia, increased heart rate, and elevated blood pressure

Additionally, studies have shown that antioxidant enzymes GPX4 and SOD1, along with the transcription factor NRF2, are involved in intracellular GSH redox reactions [29, 30]