CrossRef Organokine-Mediated Crosstalk: A Systems Biology Perspective on the Pathogenesis of MASLDA Narrative Review Sandra Maria Barbalho, Lucas Fornari Laurindo, Vitor Engracia Valenti, Nahum Mndez-Snchez, Mariana M
OBESITY AND IBD by @EdwardLoftus2 Obesity is a chronic inflammatory statue Adipose tissue is not biologically inert (TNFa, IL-6, IL-8, leptin, adiponectin) Postulated role in the pathogenesis of IBD Potential risk factor for adverse outcomes Trends in BMI among IBD patients at diagnosis in Olmsted County, Doubling of obesity rates in 20 years in CD and UC (Johnson AM JCC 2021 and J Clin Gastro 2024) Obese patients more likely to have a colonic phenotype
The Good: Why GLP-1 Medications Cause Rapid Weight Loss GLP-1 medications work by mimicking a naturally occurring hormone called glucagon-like peptide-1, which helps regulate blood sugar and appetite
Weeks 9 through 12: 4 mg weekly What is happening: This is where retatrutide starts to differentiate itself from single and dual-agonist compounds
What GLP-1 drugs are available
There are no approved transdermal versions of semaglutide or similar drugs