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In addition, we refer readers to Addendum D1 to this final rule with comment period for the status indicator meanings reported under OPPS

One 2026 narrative review concluded that GLP-1 receptor agonist therapy is associated with meaningful nutritional deficiencies and that individualized nutritional assessment and lab evaluation may be appropriate, especially in people at higher risk of malnutrition

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Although HLA-DR2 has been identified as a major genetic risk factor for MS its direct association with Cbl deficiency remains uncertain