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Emerging evidence indicates marked differences between primary and metastatic lesions in terms of metabolite composition, mitochondrial activity, ROS levels, and the architecture of the tumor microenvironment [17,18,19,20]

The additional significant decreases in HbA1c and weight remained in favor of tirzepatide after further regression adjustments (Supplementary Table S4)

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Monitoring as Metabolic Control Since many relevant metabolic perturbations remain subclinical, monitoring becomes a proactive control strategy rather than a purely diagnostic measure