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Tirzepatide (Mounjaro) has produced some of the largest weight-loss results seen with this class in obesity trials [9], though GI side effects can be strong early on

Key highlights Retatrutide is a next-generation weight loss medication that activates GLP-1, GIP, and glucagon receptors simultaneously to promote appetite suppression, improve metabolic health, and increase energy expenditure

7 Further, rapid weight loss can lead to rebound weight gain, something known as weight cycling

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Neumiller, Mindy M

Topical local antipruritics | Treatment summaries BNF NICE