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Acknowledgements We are grateful to Shinji Sakai, Shinji Deguchi, Kana Furukawa for animal care

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doi: 10.1371/journal.pone.0168390 171 LiuRZhangCShiYZhangFLiLWangXet al

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If you experience irritation, reduce usage frequency to 1-2 times per week or consult a dermatologist