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Phytochemicals such as, the Resveratrol (3,4,5-trihydroxy stilbene) and the Curcuminoids (with , -unsaturated carbonyl groups) are potential inducers of HO-1 expression through Nrf2/ antioxidant-responsive element (ARE) pathway 471,472

In summary, while intrinsic TMAO elevation is associated with unfavorable cardiovascular outcomes, inconsistent results of supplementation studies suggest that artificial elevation of TMAO fails to account for all involved mechanisms [72]

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To ensure optimal results, it is recommended to ship urine specimens to the laboratory immediately after collection as they start degrading in quality soon after

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