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The results revealed an average 14.9% reduction in body weight from baseline during 68 weeks of treatment with semaglutide 2.4 mg plus a lifestyle intervention, compared with just a 2.4% reduction in the placebo plus lifestyle intervention group

and Algarni, A.S

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Maintaining the same caloric deficit you had on tirzepatide without accounting for the additional expenditure can push you into an excessive deficit that promotes muscle loss, fatigue, and metabolic adaptation