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doi: 10.1002/j.1460-2075.1993.tb05814.x

We [also] found that semaglutide acts via a reward area [in the brain] called nucleus accumbens. The studys main limitation is that it used rats and mice

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Observed improvements may also be influenced by placebo effects or concurrent nutritional changes

Unfavorable environmental causes overproduction of ROS that leads to considerable changes in cellular lipid membrane causing peroxidation of lipids (shown by increased MDA) 52