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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

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A 64-fold increase in plasma glutathione levels means the difference between a supplement that shows up on a label and one that actually shows up in the bloodstream

LPS can cross the gut barrier, especially when the barrier becomes leaky due to inflammation, and enter the bloodstream, triggering systemic inflammation

A key limitation in translating these benefits into clinical practice lies in the low bioavailability of polyphenols