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Biosci Biotechnol Biochem 68:18421848 Houdek HM, Larson J, Watt JA, Rosenberger TA (2014) Bacterial lipopolysaccharide induces a dose-dependent activation of neuroglia and loss of basal forebrain cholinergic cells in the rat brain
The mean BMI was approximately 25.3 kg/m2
In line with strong and stable interactions of His1-Ala2 of GLP-1 compared with transient interactions of His1-Gly2 in exendin-4, truncation of these two N-terminal residues reduces GLP-1 affinity by 100-300 fold, whereas for exendin-4, this has no effect, albeit for both peptides, these residues are required for GLP-1R-mediated cAMP production 2225
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Given the many surprising results reported in the past, some unexpected findings might even boost this development further
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