ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1
Key points Abdominal pain in chronic constipation (FC/IBS-C) stems from fecal/gas distension, gut dysbiosis (e.g., histamineproducing bacteria), serotonin imbalances (linked to IBS-C pain), and neural dysfunction (central/peripheral sensitization)
Frequently studied in cellular signalling pathway research
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