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Lancet Diabetes Endocrinol 8:535545

Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree

Other At-Risk Groups GLP-1 medications are generally not suitable for individuals with severe gastrointestinal disorders like gastroparesis, those with type 1 diabetes (as these drugs are approved only for type 2 diabetes and obesity), and people with a history of suicidal thoughts, active eating disorders, or heavy alcohol use

The medication's therapeutic effects depend on consistent administration and gradual dose escalation rather than the specific day of initiation

Key exclusions included CKD due to causes other than type 1 diabetes, prior kidney transplantation, symptomatic heart failure with reduced ejection fraction, and recent use of flozins or GLP-1 RAs