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Common plateau scenarios include: The circulation bottleneck: repair stalls because nutrient delivery is insufficient The remodeling bottleneck: pain improves but stability does not return The inflammation bottleneck: repair attempts are repeatedly interrupted by flare cycles The structure bottleneck: collagen forms but remains disorganized and weak GLOW is designed to support these simultaneously
Many animals do not survive
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J Biol Chem 281 : 1050810515
Schweizer PA, Duhme N, Thomas D, Becker R, Zehelein J, Draguhn A, Bruehl C, Katus HA, Koenen M (2010) cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control
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