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The search included terms such as small molecule GLP-1 receptor agonists, oral GLP-1 receptor agonists, Danuglipron, Orforglipron, and Aleniglipron. Additionally, information on ongoing clinical trials involving small molecule GLP-1 receptor agonists was retrieved from the ClinicalTrials.gov database using the same keywords

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Any patient currently on tirzepatide 15 mg who wants to trial retatrutide should discontinue tirzepatide first, allow at least two weeks for GI recovery, and begin retatrutide at the 2 mg starting dose with standard titration [2][4]

Yadav, H., Lee, J.-H., Lloyd, J., Walter, P., & Rane, S

One study found that weekly treatment with semaglutide, a GLP-1 RA, reduced the risk of a combination of stroke, heart attack, and death from cardiovascular causes by 20% compared with placebo.