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GLP-1 protocols: Which drug do you recommend for my metabolic profile, and why

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In a small randomized crossover trial, daily 15mg of pioglitazone in CAPD patients (both with and without DM) showed improved insulin resistance, adipokine balance, with reduced markers of inflammation.40 In the diabetic PD population, pioglitazone may be continued without any dose adjustments on PD-free days without increases risk of hypoglycemia.24 The main drawback to its use is related to its adverse effect profile on fluid retention, meaning that it is usually an alternative to other agents with a better safety profile

These medications work by mimicking the action of GLP-1, a naturally occurring hormone released by the intestine after eating