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On the other hand, other authors have shown that MPP + induces negative effects in astrocytes, such as loss of viability, impairment of energetic metabolism of mitochondria, ROS generation and decrease in the glutamate clearance by astrocytes [81,85,86]

Ammoniaand its associated nitrogenis a toxic byproduct that requires activation of the urea cycle for homeostasis and prevention of ammonia toxicity