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The primary triggering mechanism is the occurrence of cardiac arrhythmias such as ventricular fibrillation or the unmasking of previously unrecognised channelopathies

For Wegovy, this includes personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, history of pancreatitis, severe hepatic impairment, and pregnancy

Persistent severe symptoms that interfere with daily activities or lead to dehydration should prompt immediate medical consultation, as medication discontinuation or alternative treatments may be necessary

Intrinsically photosensitive retinal ganglion cells detect light with a vitamin A-based photopigment, melanopsin

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