This includes eating a balanced diet, exercising regularly, and avoiding smoking, all of which can improve both blood sugar levels and eye health
Efficacy Type 2 Diabetes SURPASS-2 Trial A direct comparison between tirzepatide and semaglutide in the SURPASS-2 trial demonstrated: HbA1c reduction : Tirzepatide (15 mg): up to 2.3% Semaglutide (1 mg): 1.9% Average weight loss : Tirzepatide: 5.5 kg Semaglutide: 3.8 kg Meta-Analysis Findings A meta-analysis of multiple trials confirmed tirzepatides superiority: 5 mg dose : 1.5 higher odds of achieving 5% weight loss than semaglutide 10 mg dose : 3.0 higher odds 15 mg dose : 4.2 higher odds However, higher tirzepatide doses also led to slightly higher discontinuation rates due to gastrointestinal side effects
In May 2022, tirzepatide received its first approval in the USA to improve glycaemic control in adults with T2DM, as an adjunct to diet and exercise
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These over-the-counter choices carry no significant interaction risk with GLP-1 therapy and provide relief within 30-60 minutes
Common side effects include nausea, diarrhea, constipation, vomiting, decreased appetite, and indigestion