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9:00 - ASSAY DEVELOPMENT FOR PYRUVATE DEHYDROGENASE KINASE INHIBITOR DISCOVERY Nathan Lilla University of Nebraska at Kearney Pyruvate dehydrogenase kinase (PDK) regulates the activity of the pyruvate dehydrogenase complex (PDC) by phosphorylating its E1 subunit, thereby limiting conversion of pyruvate to acetyl-CoA, restricting entry into the TCA cycle, and reducing ATP production

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3.3 Mediation analysis of GLP-1RAs on ED We conducted a two-step MR analysis to investigate the mediating pathway from GLP-1RAs to ED via two GLP-1RAs related indications, including T2D and obesity

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Incretin hormone agonists: Current and emerging pharmacotherapy for obesity management

Together, the TRIUMPH, TRANSCEND, and SYNERGY programs represent one of the most comprehensive Phase 3 development programs in obesity pharmacotherapy