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Additionally, the C-terminal fragment is often targeted in drug design to improve receptor specificity and therapeutic efficacy while minimizing degradation by proteases such as fibroblast activation protein (FAP), which cleaves the C-terminus and inactivates FGF-21

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Key natural products, their phytoconstituents, and pharmacological activities relevant to GI disorders are summarized in Table 2 , 37,164194 while their integrative therapeutic mechanisms are illustrated in Figure 3

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Until more data emerge from ongoing and future clinical trials, enclomiphene will not be integrated into official treatment guidelines or become a mainstream testosterone therapy

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