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In some embodiments, the active principles are chosen from principles for use in the cosmetics or agrifood industry or sports medicine or from diagnostic agents

Metal-based nanomaterials, characterized by degeneration in the TME, can be designed for programmed release of payloads in response to physiological stimulation

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Copper is a cofactor for lysyl oxidase (the enzyme that crosslinks collagen and elastin), superoxide dismutase (a critical antioxidant enzyme), and numerous other copper-dependent enzymes involved in tissue maintenance

TB-500 is a synthetic form of the active region of Thymosin Beta-4, a naturally occurring peptide studied for its role in cell migration and actin regulation in laboratory models