Using web-based protease cleavage site prediction tools, we show that M pro may be targeting not only GPX1, but several other selenoproteins including SELENOF and thioredoxin reductase 1, as well as glutamate-cysteine ligase, the rate-limiting enzyme for glutathione synthesis
First, basic insights into OA and ferroptosis confirm that OA progression involves cartilage degeneration, subchondral bone remodeling, and synovial inflammation, in addition to oxidative stress and various cell death modalities
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