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So, when it was time to try a GLP-1, he already had the process down

The clinical translation of these trial results, which will be important for the comparison of GLP-1RAs with SGLT2 inhibitors in the treatment of patients with heart failure and a preserved ejection fraction, remains to be determined

Peer reviewer reports are available

How Dose Titration Works Why start low Gradual titration is standard practice across the GLP-1 drug class

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For the highest dose group (12 mg), this is what the titration schedule looked like: Weeks 1-4 : 2 mg once weekly Weeks 5-8 : 4 mg once weekly Weeks 9-12 : 8 mg once weekly Weeks 13 onward : 12 mg once weekly What phase 3 trials show so far: Testing long-term dosing of retatrutide In more recent phase 3 trials , the doses used are a bit different, but the overall structure still follows that same gradual, step-by-step pattern