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Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice

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Regulatory agencies, medical professionals, and the public must work together to ensure that treatments are both safe and effective

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Evidence has shown their capability to increase the expression of NRF2 target genes in cellular and in vivo models of chronic obstructive pulmonary disease (COPD) [298], and to interfere with the direct PPI between KEAP1 and NRF2 or the PPI between KEAP1 and CUL3 [299, 300]