These enzymes play key roles in glycolysis, glutaminolysis, and fatty acid oxidation
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The third term is the rate of production of oxidized GSSG from GSH via the enzyme GPX and the fourth term is the conversion of GSSG back to GSH via the enzyme GR
This direct scavenging neutralizes unstable radicals such as superoxide, hydroxyl radicals, and lipid peroxyl radicals before they can tear through the cellular membrane
PMID: 40958476 J Adv Res Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy
We produce free radicals in our own bodies just from the oxygen we take in, but were also exposed to free radicals on the outside, by the pollutants in the air, cigarette smoke, the water, the food supply, and both recreational and prescription drugs