The opposite problem
Topical application of GHK-Cu dressings 2 daily for 8 weeks vs standard wound care
155 Likewise, a large clinical trial performed in China (where folic acid fortification is voluntary) tested different doses of folic acid in 2,163 patients with high blood pressure and homocysteine levels of 10 mol/L or higher and found homocysteine lowering was maximized at 1,200 mcg of folic acid daily
Oxygen consumption, which is essential for life, contributes to the generation of reactive oxygen species (ROS) within cells [9]
You assume the peptide is inactive at the tested concentration
In CuCP complex, which constitutes approximately 75% from the total copper pool (our data and 4,5 ), the copper ions are bound in protein interior, which makes them kinetically inert and practically nonexchangeable at physiological pH values even in the presence of high millimolar concentrations of powerful Cu(II)-chelating ligands like EDTA or DTPA