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Individuals without insurance coverage may still obtain GLP-1 medications through direct-purchase channels, but cost remains a barrier for many

Safety and Tolerability of GLP-1RAs for the Treatment of Obesity Since GLP-1RA therapy is used for the treatment of type 2 diabetes, there may be concerns about whether using an antidiabetic medication to treat obesity will increase the risk of hypoglycemia in people with obesity but without diabetes

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This has led to the development and investigation of several incretin-related therapies such as unimolecular GLP-1/glucagon receptor dual agonists, GLP-1/gastric inhibitory polypeptide (GIP) dual agonists and GLP-1/GIP/glucagon receptor triple agonists