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Use in pregnancy is not recommended unless the potential benefit justifies the potential risk to the fetus

These drugs administered without proper supervision could cause a minefield of health and emotional problems for children as they age. Cooper also noted that conditions like pediatric obesity have become epidemic in large measure because of environments without adequate venues for safe play and exercise for children and adolescents coupled with the availability of popular, inexpensive, high-calorie fast-foods

This same review noted that athletes and those who are physically active who supplement with creatine benefit from its water-attracting (osmotic) properties, which may help athletes stay hydrated for increased strength, endurance, and resistance to fatigue

Thomas et al., 2020b

If not addressed, insufficient B12 levels can impact the production of red blood cells, nerve function, and overall vitality