REST directly binds to the promoter region of glutamate-cysteine ligase (GCLM), inhibits the synthesis of GSH through transcriptional inhibition of GCLM expression, and induces ferroptosis
Chikhale, University of Cambridge, United Kingdom Reviewed by Namde Jadhav, Krishna Institute of Medical Sciences Deemed University, India Kumaraswamy Gandla, Chaitanya (Deemed to be University), India Jayadev Hiremath, BVVS Hanagal Shri Kumareshwar College of Pharmacy, India Updates Copyright 2025 Revankar, Patil, Karishetti, Chougule, Patil and Salokhe
If the glutathione levels within these power plants drop, the cells can become sluggish or damaged
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Similar procedures were followed to extract digesta samples but with (1:4 w/v) dilution congruent to the concentration of target substrate in digesta
