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Time of day doesnt matter for semaglutide or tirzepatide

Tryptic peptides (cleavage at R,K) with a minimum length of 7AA, a maximum of two missed cleavages, oxidation (M), and acetylation (CKHSTY) (Unimod #1) as variable modifications were considered

2 However, since GLP-1 is easily degraded within a few minutes by dipeptidyl peptidase 4 (DPP-4), the GLP-1 receptor agonist such as Exenatide and Liraglutide are used to prolong this effect

References

DOI: 10.1016/s0272-6386(03)00110-0 Malaguarnera M, Cammalleri L, Gargante MP, Vacante M, Colonna V, Motta M

doi:10.1074/jbc.M706204200 Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ