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These conclusions are supported by the observation that the positive inotropic effect of retatrutide was attenuated, in part, by a GIP receptor antagonist, in part by a glucagon receptor antagonist and in part by a GLP-1 receptor antagonist

Doetsch F, Caill I, Lim DA, Garca-Verdugo JM, Alvarez-Buylla A

As endogenous GLP-1 has a very short half-life, these central actions are likely to be more relevant during therapeutic use of DPP4-resistant GLP-1R analogs, or in post-gastric bypass surgeries, in which GLP-1 equivalent levels, or postprandial GLP-1, respectively, are augmented and sufficient to elicit anorectic responses at these CNS targets

Yaksh,T.L., Kokotos, G., Svensson, C.I., Stephens, D., Kokotos, C.G., Fitzsimmons, B., Hadjipavlou-Litina, D., Hua, X.Y

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Getting it without your doctors okay can be very dangerous