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Contraindications to Semaglutide include: a personal history of pancreatitis, alcohol abuse, renal impairment, uncontrolled psychiatric disorders, personal or family history of medullary thyroid carcinoma (MTC), or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), and if you are pregnant or breastfeeding

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This is often the case in conditions like Hashimotos thyroiditis