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71 It has been shown to induce and maintain remission in patients with moderate to severe UC
NAD+ Preservation and Sirtuin Activation First and most directly, NNMT activity consumes nicotinamide, which is a key precursor for NAD+ biosynthesis through the salvage pathway (the predominant NAD+ synthesis route in most mammalian cells)
Its used to treat B12 deficiency
Revolutionary NNMT Inhibition Mechanism 5-Amino-1MQ functions as a potent selective inhibitor of nicotinamide N-methyltransferase with IC = 1M, preventing the enzyme from converting nicotinamide to 1-methylnicotinamide
Because the body cant produce Vitamin B12 on its own, it must come from animal-based foods or supplements
Its important to watch closely and teach patients about these risks
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