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These medications work by mimicking the action of naturally occurring incretin hormones, which stimulate insulin secretion in response to food intake, suppress glucagon release, slow gastric emptying, and promote satiety through central nervous system pathways
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doi: 10.1080/00365521.1997.11720715 13 GillSRPopMDeboyRTEckburgPBTurnbaughPJSamuelBSet al
Individuals who are pregnant/breastfeeding or may become pregnant while on GLP-1 injections should not take this medication
Tirzepatide works with both GLP-1 and GIP receptors at the same time
The Aib substitution at position 8 plus the albumin-binding C18 fatty diacid at Lys26 together extend semaglutide's half-life to roughly 165 to 184 hours
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