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At a $245 monthly price, the new model projected that Medicare would spend nearly $74 billion on GLP-1 drugs over 10 years if coverage expanded, with about $56 billion in downstream health savings thanks to better outcomes associated with diabetes, heart disease, and related complications

After about a year without treatment with semaglutide, net weight loss was down to 5.5%

I would choose oral therapy and administer the loading dose of 140 mg per kilogram in the emergency department

For a patient at 113 kg, that is 15 kg over 72 weeks, enough to reverse prediabetes in many cases, meaningfully reduce blood pressure, and improve sleep quality

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