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This analysis showed that semaglutide (both oral and sc) reduces the continuum relative and the absolute risk of MACE, especially in medium to high-risk patients, with no difference between trials evaluating only blood glucose control or cardiovascular events, and also with studies without active comparator, only versus placebo

Plus, the company has noticed a pronounced shift in both customers adjusting the sizes listed in their online profiles and requesting smaller sizes, Baer added

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New research has also shown a separate pathway where low concentrations of GLP-1 lead to increased intracellular calcium and insulin secretion independent of the cAMP pathway (8) ( Figure 1 )