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Other drugmakers, such as Eli Lilly and Pfizer, are developing their own GLP-1s in a bid to capitalize on a weight loss drug market that some analysts project could be worth $200 billion by 2030

In 2023, total commercial spending (gross) on GLP-1 drugs in Massachusetts is projected to surpass $270 million, more than double the spending in 2022, which was nearly $125 million

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GIP also stimulates bone formation and inhibits bone resorption [38], but we dont have any clinical evidence to date of an effect on bone preservation with a GLP- 1/GIP dual agonist for weight loss

Tumour necrosis factor (TNF) released from microglia or perivascular macrophages activates the c-Jun N-terminal kinase (JNK) and inhibitor of B alpha/nuclear factor B (IB/NF-B) signalling pathways, thereby amplifying neuroinflammatory responses throughout the brain parenchyma [8]

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